Description
Numerous growth factors are in fact within the platelets and in particular a large number of them have a
specific activity on neo proliferation, on cartilage regeneration and in particular also an antiapoptotic effect
on chondroblasts:
- The PDGF which regulates the secretion and synthesis of collagen
- The EGF that causes cellular proliferation, endothelial chemotaxis, and angiogenesis
- The VEGF that increases angiogenesis and vascular permeability
- The TGF-beta that stimulates the proliferation of undifferentiated MSC, stimulates chemotaxis of endothelial cells and angiogenesis
- The bFGF that promotes the growth and differentiation of chondrocytes and osteoblasts
stimulates mitogenesis of mesenchymal cells, chondrocytes and osteoblasts